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Does anyone know much about how long Valium pills keep their ... BUT it loses potency over time. ... know much about how long Valium pills keep their strength? Hello hondagirl. The norm is a drug is discarded a year after the perscription is filled because the chemical substances will over time, diminish and lose its potency. Valium effective long term? ... I have read that valium loses it;s effect over time and i have also read that it only loses it's sedative effect and not the anti ... Does Diazepam (Valium) ... it is highly likely that USP acceptable potency would be the norm over that same time period. ... - loss of coordination.

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